ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of paroxetine tablet in Chinese healthy volunteers.</p><p><b>METHODS</b>Twenty healthy subjects received a single oral dose of 40 mg paroxetine tablet. The plasma concentrations of paroxetine were determined using high-performance liquid chromatography (HPLC) and the measurements were analyzed with 3P97 program.</p><p><b>RESULTS</b>The plasma concentration curve of paroxetine following a single oral dose administration conformed to the two-compartment open model. The main pharmacokinetics parameters of paroxetine were: C(max)64.74-/+18.43 ng/ml, T(max)5.64-/+1.84 h, t(1/2) 20.03-/+5.33 h, AUC(0-120) 976.47-/+309.49 ng.h/ml, and AUC(0-inf) 1086.75-/+376.54 ng.h/ml.</p><p><b>CONCLUSION</b>The pharmacokinetics of paroxetine in human body conforms to the two-compartment open model.</p>